How does one cell become a whole animal?
We want to know HOW CELL DIVISION CONTRIBUTES TO that, and especially...
about separase, a protein that promotes chromosome segregation and has an additional function in exocytosis
how securin regulates separase as both a chaperone and inhibitor for both its canonical and additional functions
how programmed variations of cytokinesis contribute to embryo morphogenesis
novel roles for Aurora B kinase at the apical surface of cells after abscission
How do we do all this?
We shoot lasers at fluorescent worm embryos and make movies of them.
Our favorite technique is lattice light sheet microscopy. We collaborated with Eric Betzig and Bi-Chang Chen for that.
